- Ivermectin
- Mebendazole
- Ivermectin + mebendazole (combination)
- Budesonide
- Hydroxychloroquine
- Oseltamivir (generic Tamiflu)
- Antibiotics in emergency kits
- Epinephrine auto-injectors
- Low-dose naltrexone (LDN)
- Metformin
- Tirzepatide
- Nattokinase
- N-acetylcysteine (NAC)
- Vitamin D (and K2)
- Vitamin C, zinc and quercetin
- Magnesium
- Turmeric and curcumin
- Omega-3s and krill oil
- Sulforaphane (broccoli sprouts)
Ivermectin
An antiparasitic medicine whose discovery won a share of the 2015 Nobel Prize. It was widely studied as a COVID-19 treatment from 2020 to 2023.
Found in: Medical Emergency Kit, Contagion Emergency Kit, Ivermectin, Ivermectin + Mebendazole (referral links)
- Meta-analysisIvermectin for COVID-19: real-time analysis of 305 studies
A real-time meta-analysis compiling 305 studies on ivermectin for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- TrialIvermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial
A randomized trial of 363 patients in Bangladesh. People given ivermectin plus doxycycline recovered about two days sooner on average and were less often still positive on day 14 than those on placebo. Listed by c19early.org.
- TrialIvermectin shows clinical benefits in mild to moderate COVID19: a randomized controlled double-blind, dose-response study in Lagos
A small double-blind trial of 62 patients in Nigeria. Time to a negative test was shorter on ivermectin, and shortest at the higher dose. Listed by c19early.org.
- FDA labelStromectol (ivermectin) tablets: prescribing information
The FDA-approved label. Lists the approved uses (strongyloidiasis of the intestine and onchocerciasis), dosing, side effects and drug interactions.
- AgencyThe Nobel Prize in Physiology or Medicine 2015: press release
Announces the prize shared by William Campbell and Satoshi Ōmura for discovering avermectin, the parent of ivermectin, and its impact on river blindness and lymphatic filariasis.
- ReviewIvermectin, ‘wonder drug’ from Japan: the human use perspective
A history of ivermectin in human medicine, written by Andy Crump and Satoshi Ōmura, covering its use in mass drug-donation programs against parasitic diseases.
- NewsFDA settles lawsuit over ivermectin content that doctors claimed harmed their practice
Reports that the FDA agreed to remove its “You are not a horse” posts and retire a consumer update after three doctors sued. The FDA admitted no wrongdoing and did not change its position on COVID-19 use.
Mebendazole
A deworming medicine used for intestinal worm infections.
Found in: Ivermectin + Mebendazole (referral links)
- Meta-analysisMebendazole for COVID-19: real-time analysis of 6 studies
A real-time meta-analysis compiling 6 studies on mebendazole for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- FDA labelEmverm (mebendazole) chewable tablets: prescribing information
The FDA-approved label for treating pinworm, whipworm, roundworm and hookworm infections, with dosing and warnings.
- ReviewEfficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis
Compared standard deworming drugs across trials. A single dose of mebendazole cured most roundworm infections but worked less well against hookworm and whipworm.
Ivermectin + mebendazole (combination)
Sources that look at the two medicines together, as in TWC’s Ivermectin + Mebendazole capsule. Neither medicine is FDA-approved for cancer.
Found in: Ivermectin + Mebendazole (referral links)
- PreprintCombination Ivermectin and Mebendazole: A Comprehensive Review of Anticancer Mechanisms, Preclinical Activity, and Clinical Evidence as Adjunctive Treatment in Cancer Patients
A review compiling laboratory and clinical studies on proposed anticancer mechanisms of ivermectin and mebendazole. It is a preprint that has not been peer reviewed, and its authors include The Wellness Company’s CEO and members of its medical leadership. It does not show that any product treats cancer.
- Social postAuthor’s announcement: “The Most Comprehensive Ivermectin–Mebendazole Cancer Paper to Date”
The lead author’s post announcing the review above, in his own words.
Budesonide
An inhaled corticosteroid listed in TWC’s Contagion Emergency Kit. It is FDA-approved for asthma.
Found in: Contagion Emergency Kit (referral links)
- Meta-analysisBudesonide for COVID-19: real-time analysis of 42 studies
A real-time meta-analysis compiling 42 studies on budesonide for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- TrialInhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial
A UK trial of 146 adults with early symptoms. Fewer people using inhaled budesonide needed urgent care, and they recovered about a day sooner than those on usual care. Listed by c19early.org.
Hydroxychloroquine
An antimalarial also used for lupus and rheumatoid arthritis. It was widely tested for COVID-19 in 2020.
Found in: Contagion Emergency Kit (referral links)
- Meta-analysisHCQ for COVID-19: real-time analysis of 636 studies
A real-time meta-analysis compiling 636 studies on hydroxychloroquine for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- FDA labelPlaquenil (hydroxychloroquine sulfate) tablets: prescribing information
The FDA-approved label covering malaria, lupus and rheumatoid arthritis, plus warnings about heart rhythm and eye effects.
Oseltamivir (generic Tamiflu)
An antiviral approved to treat and prevent influenza.
Found in: Contagion Emergency Kit (referral links)
- FDA labelTamiflu (oseltamivir phosphate): prescribing information
The FDA-approved label for treating flu within 48 hours of symptoms and for flu prevention, with dosing and side effects.
- ReviewOseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials
A pooled analysis of individual patient data from the manufacturer’s trials. It reported faster symptom relief and fewer lower-respiratory complications, along with more nausea and vomiting.
Antibiotics in emergency kits
Several kits include antibiotics prescribed in advance for possible later use. Labels and public-health guidance describe how they should and should not be used.
Found in: Medical Emergency Kit, Contagion Emergency Kit, Travel Emergency Kit, First Aid Emergency Kit, Field Emergency Kit, Kids Emergency Kit, GO Emergency Kit (referral links)
- Meta-analysisAzithromycin for COVID-19: real-time analysis of 52 studies
A real-time meta-analysis compiling 52 studies on azithromycin for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- FDA labelZithromax (azithromycin): prescribing information
The FDA-approved label for azithromycin tablets and suspension, including approved infections and warnings such as heart-rhythm (QT) effects.
- AgencyAntibiotic Prescribing and Use
CDC guidance on when antibiotics help, when they don’t (for example, most colds and flu), side effects and antibiotic resistance.
Epinephrine auto-injectors
Used for emergency treatment of severe allergic reactions (anaphylaxis).
Found in: First Aid Emergency Kit, Field Emergency Kit, Kids Emergency Kit (referral links)
- FDA labelEpiPen and EpiPen Jr (epinephrine injection): prescribing information
The FDA-approved label, including how to use the device, dosing by body weight, and the instruction to seek emergency care after use.
Low-dose naltrexone (LDN)
Naltrexone is FDA-approved at 50 mg for alcohol and opioid dependence. Doses of a few milligrams (“low dose”) are used off-label and have been studied in small trials.
Found in: Low Dose Naltrexone (referral links)
- FDA labelNaltrexone hydrochloride tablets: prescribing information
The FDA-approved label for standard-dose naltrexone, with its approved uses, warnings and interactions with opioid medicines.
- TrialPilot trial of low-dose naltrexone and quality of life in multiple sclerosis
A small crossover pilot trial in people with MS. LDN improved scores on mental-health quality-of-life measures; the authors called for more study.
- TrialLow-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial
A crossover trial in 31 women with fibromyalgia. Pain scores fell more on LDN than on placebo.
- ReviewEfficacy and safety of low-dose naltrexone for the management of fibromyalgia: a systematic review and meta-analysis
Pooled the available randomized trials and concluded LDN may reduce fibromyalgia pain, with a relatively good safety profile.
Metformin
A first-line, FDA-approved diabetes medicine that has also been studied for diabetes prevention and COVID-19.
Found in: Metformin (referral links)
- Meta-analysisMetformin for COVID-19: real-time analysis of 160 studies
A real-time meta-analysis compiling 160 studies on metformin for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- FDA labelMetformin hydrochloride extended-release tablets: prescribing information
The FDA-approved label for type 2 diabetes, including the boxed warning about lactic acidosis and kidney-function limits.
- TrialReduction in the incidence of type 2 diabetes with lifestyle intervention or metformin (Diabetes Prevention Program)
In adults at high risk, metformin lowered the rate of new type 2 diabetes compared with placebo, though an intensive lifestyle program lowered it more.
- TrialOutpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT)
Follow-up of the same trial. Fewer people who took metformin were later diagnosed with long COVID; ivermectin and fluvoxamine showed no such difference.
Tirzepatide
FDA-approved as weekly injections (Zepbound, Mounjaro). Other forms, such as compounded sublingual tablets, are not FDA-approved.
Found in: Tirzepatide (referral links)
- FDA labelZepbound (tirzepatide) injection: prescribing information
The FDA-approved label for the weekly injection, including its boxed thyroid C-cell tumor warning and common stomach side effects.
- TrialTirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
A 72-week trial of weekly injections in adults with obesity. Average weight loss was far greater than placebo; nausea and other stomach effects were common. The trial did not test tablets.
- AgencyFDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss
Explains that compounded versions are not FDA-reviewed for safety or effectiveness, and lists warning signs to check when buying through telehealth.
Nattokinase
An enzyme from natto, a fermented soybean food. It is the main ingredient in TWC’s Spike products.
Found in: Spike Support, Ultimate Spike Detox (referral links)
- TrialEffects of nattokinase on blood pressure: a randomized, controlled trial
An eight-week trial in adults with borderline or early high blood pressure found modest drops in blood pressure on nattokinase compared with placebo.
- TrialA single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles
A small study in 12 healthy young men. One dose shifted several clot-breakdown and clotting markers over the following hours, all within normal ranges.
- Lab studyDegradative Effect of Nattokinase on Spike Protein of SARS-CoV-2
A laboratory study showing nattokinase broke down the SARS-CoV-2 spike protein in test tubes and cell cultures. It was not a study in people.
N-acetylcysteine (NAC)
A form of the amino acid cysteine that the body uses to make glutathione. As a drug it is used for acetaminophen overdose and to thin mucus.
Found in: Ultra NAC (referral links)
- Meta-analysisN-acetylcysteine for COVID-19: real-time analysis of 49 studies
A real-time meta-analysis compiling 49 studies on n-acetylcysteine for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- ReviewN-Acetylcysteine (NAC): Impacts on Human Health
A broad review of how NAC works and the conditions in which it has been studied, from its approved medical uses to experimental ones.
Vitamin D (and K2)
Vitamin D supports calcium absorption and bone health. It has also been studied for other outcomes, including respiratory infections.
Found in: Vitamin D3 + K2 (referral links)
- Meta-analysisVitamin D for COVID-19: real-time analysis of 598 studies
A real-time meta-analysis compiling 598 studies on vitamin D for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- Meta-analysisVitamin K for COVID-19: real-time analysis of 12 studies
A real-time meta-analysis compiling 12 studies on vitamin K for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- ObservationalCalcifediol Treatment and COVID-19-Related Outcomes
An observational study of 838 hospitalized patients in Barcelona. Those given calcifediol, a form of vitamin D, were admitted to intensive care and died less often than those who were not. Listed by c19early.org.
- AgencyVitamin D: Fact Sheet for Health Professionals
Covers recommended intakes, deficiency, safe upper limits and a summary of research on bones, cancer, heart disease and more.
- AgencyVitamin K: Fact Sheet for Health Professionals
Explains the K1 and K2 forms, their role in blood clotting and bone, and the interaction with the blood thinner warfarin.
- ReviewVitamin D supplementation to prevent acute respiratory tract infections: individual participant data meta-analysis
Pooled data from 25 trials found fewer respiratory infections with vitamin D, especially among people with very low starting levels who took it daily or weekly.
Vitamin C, zinc and quercetin
Common ingredients in immune-support formulas, including Liposomal Vitamin C and Natural Immunity.
Found in: Liposomal Vitamin C, Natural Immunity (referral links)
- Meta-analysisVitamin C for COVID-19: real-time analysis of 177 studies
A real-time meta-analysis compiling 177 studies on vitamin C for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- Meta-analysisZinc for COVID-19: real-time analysis of 206 studies
A real-time meta-analysis compiling 206 studies on zinc for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- Meta-analysisQuercetin for COVID-19: real-time analysis of 122 studies
A real-time meta-analysis compiling 122 studies on quercetin for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- TrialTwice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial
A multicenter trial of 470 patients in Tunisia. The zinc group had fewer ICU admissions and a lower combined rate of death or ICU admission than placebo, and outpatients had shorter symptoms. Listed by c19early.org.
- AgencyVitamin C: Fact Sheet for Health Professionals
Recommended intakes, food sources, upper limits and research summaries for vitamin C.
- AgencyZinc: Fact Sheet for Health Professionals
Recommended intakes, upper limits, interactions and research on zinc and the common cold.
- TrialQuercetin as a possible complementary agent for early-stage COVID-19: concluding results of a randomized clinical trial
A small open-label trial (100 patients) reported faster test clearance and symptom improvement with quercetin. Several authors work for the supplement’s supplier.
Magnesium
An essential mineral involved in muscle, nerve and bone function, often taken for sleep.
Found in: Magnesium Complex (referral links)
- AgencyMagnesium: Fact Sheet for Health Professionals
Recommended intakes, deficiency, upper limits for supplements, and interactions with medicines.
- TrialThe effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial
A trial of 46 older adults in Iran reported better sleep scores and some hormone changes on magnesium compared with placebo.
Turmeric and curcumin
Turmeric root contains curcumin, which is poorly absorbed on its own. Research is extensive but uneven in quality.
Found in: Ultimate Spike Detox, Turmeric Extract (referral links)
- Meta-analysisCurcumin for COVID-19: real-time analysis of 111 studies
A real-time meta-analysis compiling 111 studies on curcumin for COVID-19, kept by an independent website. It is not peer reviewed. Source: c19early.org.
- TrialOral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial
A trial of 140 hospitalized patients in India. Those given curcumin with piperine alongside usual care recovered from symptoms sooner and had fewer deaths than the usual-care group. Listed by c19early.org.
- AgencyTurmeric
A plain-language summary of what is known about turmeric, its safety (including rare liver injury reports) and gaps in the research.
- ReviewEfficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: a systematic review and meta-analysis
Pooled eight small trials and found turmeric extracts reduced arthritis pain scores versus placebo, while calling for larger, more rigorous studies.
Omega-3s and krill oil
Krill oil supplies the omega-3 fats EPA and DHA, the same ones found in fish oil.
Found in: Antarctic Krill Oil (referral links)
- AgencyOmega-3 Fatty Acids: Fact Sheet for Health Professionals
Sources, intakes and a summary of research on heart, brain and eye health, including krill oil.
- TrialKrill oil supplementation lowers serum triglycerides without increasing LDL cholesterol in adults with borderline high or high triglycerides
Pooled results across krill-oil doses showed a roughly 10% drop in triglycerides versus placebo; the authors wanted larger studies to confirm it.
- TrialEffects of krill oil and lean and fatty fish on cardiovascular risk markers: a randomised controlled trial
Compared krill oil with eating fish. Both raised blood omega-3 levels, with different small effects on other heart-risk markers.
Sulforaphane (broccoli sprouts)
A compound formed from broccoli sprouts that has been studied in small human trials.
Found in: Broccoli Sprouts (referral links)
- ReviewBroccoli or Sulforaphane: Is It the Source or Dose That Matters?
A review of human studies showing that how much sulforaphane the body actually gets varies widely by product and preparation.
- TrialSulforaphane treatment of autism spectrum disorder (ASD)
A small trial in 44 young men reported better behavior scores on sulforaphane than placebo; the scores returned toward baseline after it stopped.
Links checked October 22, 2026. Product-ingredient pairings are based on The Wellness Company’s product pages.